TUBERCULOSIS IN RABBITS Development of the Disease after intravenous Infection with Mycobacterium avium

Cerny, L.: Histopathology and Histochemistry of Yersin Type Tuberculosis in Rabbits. Development of the Disease after intravenous Infection with Mycobacterium avium. Acta vet. Bmo, 48, 1979: 45-52. After intravenous aplication to rabbits of Mycobacterium avium the first morphological changes appeared 48 hours post infection. The most characteristic morphological feature of the infection was a strong proliferation of the cells of mononuclear macrophage system. Epitheloid cells were formed 7 days after infection and multinucleated giant cells appeared after the 10th day. In following intervals the process grew enormously above all in the liver and spleen. In this period the number of mycobacteria increased and this process was evident also in the cytoplasm of epitheloid cells. Starting from the 14th day after infection epitheloid cells in the center of larger foci underwent necrobiotic changes. Tuberculosis, Mycobacterium avium, Yersin type, macrophages, epithelaid cells, giant